Parkinson’s Drug Withdrawal Symptoms Felt by Some Patients

By Jim Greene

Published on February 03, 2010

Parkinson's disease (PD) patients who cut back on prescription drugs known as dopamine agonists can suffer withdrawal symptoms similar to those experienced by users of illicit drugs, according to researchers. This can create a dilemma, since the prescription drugs may have dangerous side effects.

In a study released by the Weill Cornell Medical Center of New York City, symptoms including anxiety, panic attacks, pain, dizziness, and drug cravings were linked to disruption of dopamine levels in the brain.

Mirapex, Requip Used to Simulate Dopamine Effect

Dopamine agonists, such as Mirapex® (pramipexole) and Requip® (ropinirole) simulate the effects of naturally occurring dopamine, which helps transmit nerve signals in the motion control centers of the brain. PD patients' brains produce insufficient quantities of dopamine, leading to symptoms such as involuntary tremors, stiffness, and slowed movements.

Restless leg syndrome is also treated with dopamine agonists, to relieve involuntary twitching.

Senior study author Dr. Melissa Nirenberg said the similarity between withdrawal from dopamine agonists and drugs such as cocaine and methamphetamines is not surprising, since each stimulates the reward centers of the brain, leading to the same adverse effects when withheld.

Lawsuits Filed over Alleged Side Effects

While some patients may have difficulty withdrawing from dopamine agonists, the makers of Mirapex® and Requip® face numerous product liability lawsuits by patients who claim they suffered adverse side effects from continuing on the medication.

Some plaintiffs allege they experienced unpredictable episodes of spontaneous sleeping; including while driving or performing other tasks that could put the victim at risk. Others claim they suffered compulsive behaviors, including uncontrollable gambling, shopping, and sexual appetite.

If you or someone you know has suffered spontaneous sleeping episodes, compulsive gambling, shopping, or sexual appetite, or other symptoms while taking Mirapex®, Requip®, or other dopamine agonists, contact an experienced product liability/personal injury attorney. These side effects can result in personal liability or debt that may devastate your financial future. Your attorney will fight for the compensation needed to get your life back on track.

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