Paclitaxel / Taxol

Paclitaxel, sold under the brand name Taxol, was originally derived from Pacific Yew tree bark, but it is now made semi-synthetically. It was approved as a chemotherapy treatment for metastatic cancer of the ovaries in 1992 and for the treatment of non-small cell lung cancer in 1998. Paclitaxel is administered intravenously. In an attempt to improve the effectiveness of paclitaxel, researchers are now developing a new paclitaxel-based treatment, Xyotax.

What is Paclitaxel / Taxol?

Inside of cells are various structures and organelles. These cellular parts carry out such tasks as relaying messages, transporting materials, and assisting in mitosis. Microtubules are structures within cells that move materials and provide structural support. They are composed of tubulin strands and assist in the process of mitosis by separating duplicate, DNA-carrying chromatids from each other and by structuring new "daughter cells."

Taxol and various other "antimitotic" drugs combat cancer growths by interfering with the process of cellular division or "mitosis" within cells.

Side Effects of Paclitaxel / Taxol

Paclitaxel's most common side effects are a reduction in red and white blood cells, infection, hair loss, and nausea. Some patients may also experience an allergic reaction to the treatment. Allergies can be suppressed before treatment begins through administration of antihistamines and steroids. Xyotax, may significantly reduce these side effects.

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